Combinations ; See Below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| PZA | Cosmos Limited. | Cosmos Limited | 500mg | 100 | Tablet | per tablet | KES 600.00 |
| Pyrazina | Lupin Laboratories | Wessex Pharmaceuticals Limited | 500mg | 100 | Tablet | per tablet | KES 600.00 |
| Pyrazinamide More info | |
|---|---|
| Mode Of Action | Pyrazimide is converted by pyrazinamidase to the active metabolite,Pyrazinoic acid, which is thought inhibit the fatty acid synthetase I (FASI) of M. tuberculosis |
| Drug Indication | TB with other anti-tuberculous drugs. |
| Precautions | Hepatic/renal function, diabetes mellitus, history of gout |
| Contra-Indications | Hepatic dysfunction, safety in children and pregnancy not established. |
| Side Effects | Anorexia, fever, malaise, liver tenderness, hepatomegaly, splenomegaly, skin rashes, photosensitivity, difficult in micturition, dysuria, nausea and vomiting, sederoblastic anaemia. |
| Dosage | 15-35mg/kg/day to a max. daily dose 3g in 3-4 divided doses. Children, 20mg/kg/day. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Tuberculous Drugs |